Futurama's Planet Express located in New New York
The latest Futurama straight-to-dvd release, Bender’s Game, zooms in on the location of Planet Express, the series’ main location.
In a fictional world, in a fictional future, on a fictional eastern seaboard, in a fictional city (New New York) with a weird outline and new Hudson River crossings, Central Park remains the same. As seen in the third frame, Planet Express is on the Hudson River, southwest of Columbus Circle, in present-day Hell’s Kitchen:

A larger version of the image. The area today (Google Maps).